Neurobiology of Disease The p38 MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury
نویسندگان
چکیده
Adam D. Bachstetter,1 Rachel K. Rowe,2,3 Machi Kaneko,1 Danielle Goulding,1 Jonathan Lifshitz,4,5,6 and Linda J. Van Eldik1,2,3 1Sanders-Brown Center on Aging, 2Department of Anatomy and Neurobiology, and 3Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536, 4Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona 85004, 5Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona 85004, and 6Phoenix Veteran Affairs Healthcare System, Phoenix, Arizona 85004
منابع مشابه
The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.
Neuropathology after traumatic brain injury (TBI) is the result of both the immediate impact injury and secondary injury mechanisms. Unresolved post-traumatic glial activation is a secondary injury mechanism that contributes to a chronic state of neuroinflammation in both animal models of TBI and human head injury patients. We recently demonstrated, using in vitro models, that p38α MAPK signali...
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